Worth an Arm and a Leg: The Critical Importance of Limb Ischemia

Javier A. Valle, Stephen W. Waldo


Critical limb ischemia (CLI) represents the final stages of peripheral artery disease, reflecting impairment in tissue perfusion that leads to a threatened limb. The clinical manifestations of this condition may be broad, ranging from rest pain to severe ischemic ulceration or tissue gangrene of the extremities.

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